Publications of Kheewong Baek

Wallace, I.; Baek, K.; Prabu, J. R.; Vollrath, R.; von Gronau, S.; Schulman, B. A.; Swatek, K. N.: Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nature Communications 14 (1), 7970 (2023)

Henneberg, L. T.; Singh, J.; Duda, D. M.; Baek, K.; Yanishevski, D.; Murray, P. J.; Mann, M.; Sidhu, S. S.; Schulman, B. A.: Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nature Chemical Biology 19, pp. 1513 - 1523 (2023)

Purser, N.; Tripathi-Giesgen, I.; Li, J.; Scott, D. C.; Horn-Ghetko, D.; Baek, K.; Schulman, B. A.; Alpi, A. F.; Kleiger, G.: Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase. Biochemical Journal 480 (22), pp. 1817 - 1831 (2023)

Baek, K.; Scott, D. C.; Henneberg, L. T.; King, M. T.; Mann, M.; Schulman, B. A.: Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell 186 (9), pp. 1895 - 1911 (2023)

Scott, D. C.; King, M. T.; Baek, K.; Gee, C. T.; Kalathur, R.; Li, J.; Purser, N.; Nourse, A.; Chai, S. C.; Vaithiyalingam, S. et al.; Chen, T.; Lee, R. E.; Elledge, S. J.; Kleiger, G.; Schulman, B. A.: E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Molecular Cell 83 (5), pp. 770 - 786 (2023)

Hopf, L. V. M.; Baek, K.; Klügel, M.; von Gronau, S.; Xiong, Y.; Schulman, B. A.: Structure of CRL7(FBXW)(8) reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nature Structural & Molecular Biology 29 (9), pp. 854 - 862 (2022)

Baek, K.; Scott, D. C.; Schulman, B. A.: NEDD8 and ubiquitin ligation by cullin-RING E3 ligases. Current Opinion in Structural Biology 67, pp. 101 - 109 (2021)

Heider, L.; Eichner, R.; Stroh, J.; Morath, V.; Kuisl, A.; Zecha, J.; Lawatscheck, J.; Baek, K.; Garz, A.-K.; Rudelius, M. et al.; Deuschle, F.-C.; Keller, U.; Lemeer, S.; Verbeek, M.; Gotze, K. S.; Skerra, A.; Weber, W. A.; Buchner, J.; Schulman, B. A.; Kuster, B.; Fernandez-Saiz, V.; Bassermann, F.: The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Molecular Cell 81 (6), pp. 1170 - 1186.e10 (2021)

Horn-Ghetko, D.; Krist, D. T.; Prabu, J. R.; Baek, K.; Mulder, M. P. C.; Kluegel, M.; Scott, D. C.; Ovaa, H.; Kleiger, G.; Schulman, B.: Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly. Nature 590 (7847), pp. 671 - 676 (2021)

Kostrhon, S.; Prabu, J. R.; Baek, K.; Horn-Ghetko, D.; Gronau, S. v.; Klügel, M.; Basquin, J.; Alpi, A. F.; Schulman, B. A.: CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nature Chemical Biology 17 (10), pp. 1075 - 1083 (2021)

Shin, D.; Mukherjee, R.; Grewe, D.; Bojkova, D.; Baek, K.; Bhattacharya, A.; Schulz, L.; Widera, M.; Mehdipour, A. R.; Tascher, G. et al.; Geurink, P. P.; Wilhelm, A.; van der Heden van Noort, G. J.; Ovaa, H.; Mueller, S.; Knobeloch, K.-P.; Rajalingam, K.; Schulman, B.; Cinatl, J.; Hummer, G.; Ciesek, S.; Dikic, I.: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587, pp. 657 - 662 (2020)

Baek, K.; Krist, D. T.; Prabu, J. R.; Hill, S.; Klügel, M.; Neumaier, L.-M.; von Gronau, S.; Kleiger, G.; Schulman, B. A.: NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature 578, pp. 461 - 466 (2020)

Baek, K.; Schulman, B.: Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY 16 (1), pp. 2 - 3 (2020)

Huttenhain, R.; Xu, J.; Burton, L. A.; Gordon, D. E.; Hultquist, J. F.; Johnson, J. R.; Satkamp, L.; Hiatt, J.; Rhee, D. Y.; Baek, K. et al.; Crosby, D. C.; Frankel, A. D.; Marson, A.; Harper, J. W.; Alpi, A. F.; Schulman, B. A.; Gross, J. D.; Krogan, N. J.: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host & Microbe 26 (1), pp. 86 - 99.e7 (2019)

Baek, K.: NEDD8 orchestrates active ubiquitylation assembly of cullin-RING E3 ligase. Dissertation, Technische Universität, Fakultät für Chemie, München (2022)